Dr. Mpofu noticed that the field of dermatology tended to be neglected by black doctors, and felt she could have an effect in this field. She was sure that black people would feel more comfortable sharing their problems with a black doctor. After completing her studies as a doctor at Medunsa in 1987 she began work in cardiology at Garankuwa Hospital. She became interested in dermatology while working at the Chris-Hani Baragwanath Hospital, and went on to become the first black woman to qualify as a dermatologist through the College of Medicine in South Africa.