- 1892
- 16 March, James Sebe Moroka is born in Thaba Nchu., Bophuthatswana in the Free State province.
- 1909
- Moroka completes his primary school education, and attends the Lovedale Institute at Alice for secondary education.
- 1911
- Moroka leaves South Africa for Southampton on the ship called the Caitodonian Castle.
- Moroka is tutored for two years by Mr Fairweather and his wife towards and passes his London matric examination.
- 1913
- Moroka attends medical school in Edinburgh.
- 1918
- He returns to South Africa as a medical physician.
- Moroka marries Maggy, daughter of Chief Fenyani.
- Moroka sets up a medical practice in a rondavel in his home village in Thaba Nchu.
- 1930
- Moroka goes abroad to study surgery in Vienna, Austria.
- 1935
- December, Moroka attends the All African Convention held in Bloemfontein and is elected as the treasurer.
- 1936
- Moroka sets up a medical practice in the town of Thaba Nchu.
- Moroka is part of a delegation that meets the government to convey the attitude of Blacks towards Hertzog’s draft bills.
- 1937
- The Moroka High School is founded.
- 1942
- Moroka is elected onto the Native Representative Council from the Transvaal/ Orange Free State constituency.
- Moroka becomes involved with the African National Congress (ANC).
- 1943
- Moroka is a member of the Atlantic Charter Committee of the ANC.
- 1946
- Moroka plays a leading role in denouncing the NRC.
- 1948
- Moroka is re-elected onto the NRC.
- He attends reconciliatory talks between the AAC and the ANC.
- 1949
- December, Moroka is elected president- general of the ANC.
- 1950
- Moroka resigns from the NRC.
- 26 March, Moroka presides over the Defend Free Speech Convention, which caused a stir amongst ANC members as it committed the party to the May Day stay-at-home.
- Moroka delivers his first public address.
- 1951
- February, Moroka represents the ANC at the founding of the Franchise Action Council (FRAC).
- 1952
- Moroka is charged under the Suppression of Communism Act during the Defiance Campaign. He chooses to separate himself from the other accused.
- December, Moroka is defeated by Albert Luthuli as president general of the ANC.
- 1976
- Moroka retires as a medical practitioner.
- 1985
- 10 November, Moroka dies at Thaba Nchu.
- 1993
- 6 February, Nelson Mandela visits the grave of Moroka in Thaba Nchu.
- 2012
- 27 April, Moroka is posthumously awarded the Order of Luthuli. The order is bestowed upon him by President Jacob Zuma on National Freedom Day celebrations at the Union buildings in Pretoria.